Mezić Research Group

Dynamical Systems and Nonlinear Control Theory

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Dynamics of self assembling protein molecules

Gunjan Thakur

gunjan1We are interested to study the mechanism governing the super molecular assembly of proteins in biological systems from the dynamics point of view

gunjan2There is a considerable interest in the mechanism governing the super molecular assembly of proteins in biological systems. Recently discovered families of proteins, called silicatines, are interesting candidates for the use in nano-biotechnology. In certain sponges these proteins are responsible for silica biosynthesis. Experiments done in-vitro suggest that the silicatein monomers self assemble in a fractal sheet intermediate , which due to certain thermal instabilities fold into long filaments. We are interested to study this mechanism from the dynamics point of view to explain the whole folding process. We have been able to model the process and are working in order to address the global and local stability issues.

Last Updated on Monday, 27 April 2009 13:43  

Acknowledgements